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Its active ingredient, semaglutide, is part of a drug class called GLP-1 receptor agonists

Persistently elevated concentrations of CRP, TNF-, and IL-6 contribute directly to insulin resistance through serine phosphorylation of IRS-1, impair vascular endothelial function through suppression of endothelial nitric oxide synthase (eNOS) activity, and accelerate the progression of macrovascular disease through promotion of atherogenic lipid modification, foam cell formation, and plaque instability

Practical application for GLP-1 patients: 3 RF sessions per week of 12 to 15 minutes each, focusing on the mid-face, jawline, and any zone showing volume loss (most often temples, cheeks, marionette lines, and pre-jowl sulcus)

Conclusions: This study found that avoiding hyperphagia decreases the burden of PWS and that these results are robust, even once imposing strict inclusion criteria