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Blautia, Coprococcus ), while these changes were absent with saxagliptin, consistent with its neutral effect on body weight ( Lachnospiraceae and partially reversed dysbiosis, while semaglutide uniquely increased Helicobacter , the only taxon negatively correlated with body weight ( Clostridium abundance and negatively correlated with renal injury markers, further supporting a microbiota-mediated mechanism ( Akkermansia ), further hinting at a positive remodeling of the gut ecosystem ( Interpretation of preclinical microbiome findings should consider the inherent limitations of rodent models

These include modulation of neuroinflammation, enhancement of mitochondrial function, and promotion of neurogenesis

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Stress hormones can blunt glucagon receptor effects