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Potential complementary evidence of GLP-1RAs and SGLT2is In a meta-analysis comparing the effects of GLP-1RAs with SGLT2is, five GLP-1RA (ELIXA, LEADER, SUSTAIN-6, EXSCEL, and Harmony Outcomes) and three SGLT2i trials (EMPA-REG OUTCOME, CANVAS Program, and DECLARE-TIMI 58) with a total of 77,242 patients were include [35]

With respect to lowering of body weight, a significant dose-dependent effect was evident with tirzepatide even when compared with the GLP-1 RAs semaglutide and dulaglutide

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For example, some patients with Medicare discovered their expensive GLP-1 therapy (for CV risk reduction) was denied without explanations, leading to legal and public policy debate ( [21] ) ( [65] )