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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

Metformin. StatPearls [Internet], August 17, 2023

Last updated: January 28, 2026 As GLP-1 medications like Ozempic, Wegovy, and Mounjaro help more patients achieve significant weight loss, many are discovering that reaching their goal weight reveals new concerns: stubborn fat pockets and loose abdominal skin that diet and exercise cannot address

If you have pre-existing liver disease, this interference could exacerbate your condition