glp-1 and gip mechanism of action The signaling at homeostasis Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP)

Complications From Gastroparesis/Stomach Paralysis The National Institute of Diabetes and Digestive and Kidney Diseases lists a range of complications that can arise from gastroparesis: Dehydration from repeated vomiting Malnutrition stemming from poor nutrient absorption Difficulty controlling blood sugar (blood glucose) levels Low-calorie intake Decreased quality of life Bezoars (solid mass of food in the stomach, preventing digestion), which can cause: Blockage Ulcers Bleeding If a bezoar keeps food from moving to the small intestine, gastroparesis can be life-threatening

doi: 10.1016/j.neuropharm.2013.08.005 133 McCleanP

Its especially helpful for first-time GLP-1 users

The spatial convergence map for ghrelin resembles the dopamine motive system (Volkow et al., 2017), which is equipped with several metabolic receptors including GHSR and communicates with other networks that are involved in food intake, such as projections from the hindbrain and hypothalamus that forward homeostatic feedback (Howick et al., 2017