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Some research suggests that the glucagon component may have muscle-sparing properties compared to pure GLP-1 agonists, but this requires further study

Furthermore, GLP-1-based medications such as GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, have been shown to improve diabetes control in preclinical and clinical trials with human subjects

Given the significant benefits associated with these medications, adverse side effects that lead to drug discontinuation warrant the consideration of a specialist consultation before withdrawal of treatment

The letter did not cite manufacturing, safety, or medication quality problems