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Description
2 Synthetic GLP-1RAs are structurally modified analogues engineered to resist dipeptidyl peptidase-4 cleavage, prolonging their half-life
injections of 100 nmol kg 1 GLP-1MK-801, 10 nmol kg 1 semaglutide or vehicle (isotonic saline) based on baseline running wheel distance measurements, such that each group had similar average running wheel distances at the day of study initiation
A steady state in plasma concentrations is achieved after four once-weekly injections
GLP-1 receptor agonists, combined with tools like Wesper, support a multifaceted approach to treatment
