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& Yuriev, E

GLP-1 directly activates POMC/CART neurons and indirectly inhibits, via GABAergic transmission, the neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, which collectively results in signals that reduce food intake
This allows multiple needle punctures of the same vial over a 28-day period essential for multi-dose peptide reconstitution in laboratory settings

Think of it as a handshake, not a punch
