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What is GLP-1 GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone in the body playing an important role in sugar metabolism

Early CVOTs on GLP-1RAs, such as the LEADER, Harmony Outcomes, REWIND, and SUSTAIN-6 trials, focused on patients with T2DM and demonstrated the cardioprotective effects of these agents, including liraglutide, albiglutide, dulaglutide, and semaglutide.[811] The potential cardiovascular benefits of GLP-1RAs in patients without diabetes remain an active area of research

Recent pharmacovigilance studies have attempted to quantify this association