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Probiotics alone are rarely transformative but can support the microbiome changes that make fermentable fiber more effective, an important part of a natural alternative to GLP1 strategy

There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

In the ongoing trial, scientists have been testing whether the procedure can stimulate the growth of new, healthy tissue and result in a sustained metabolic reset

As a secondary end-point, a direct comparison with liraglutide (up to 1.8 mg) was made