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The researchers reported that mRNA expression levels of PDGF-A and PDGF-B at 30 weeks of age were increased to 3.7-fold and 4.6-fold, respectively in DBA/2FG-pcy mice that indicate a significant role of PDFG in the progression of cystic kidney disease (Nakamura et al

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In the phase 2 clinical trial, 3-26% of patients who used retatrutide experienced vomiting, compared to 1% in the placebo group