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Acknowledgements The authors would like to thank Lotte Majbrith Badeby, Henning Gustafsson, Berit Bugge Nielsen, Lisette Gammelgaard Nielsen, Betina rtberg Olsen, Lene Von Voss and Pia Von Voss for expert technical assistance

The vast majority of the disease's genetic architecture is non-Mendelian, driven by polygenic risk factors interacting with environmental triggers that remains largely uncharacterized [46, 48, 54]

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This suggests that retatrutide may be a more effective option for individuals seeking significant weight loss