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Providing a treatment option that is proven to lower this cardiovascular risk is a major advance for public health. The FDAs decision is largely based on data from the SELECT trial, which included more than 17,000 overweight or obese patients with a baseline age of 45 years old

Who Should Not Use GLP-1 Medications According to standard clinical guidelines and prescribing information, GLP-1 medications may not be appropriate for individuals who: Have a personal or family history of medullary thyroid carcinoma Have multiple endocrine neoplasia syndrome type 2 Have a history of pancreatitis Have severe gastrointestinal disease (gastroparesis, inflammatory bowel disease) Are pregnant, planning to become pregnant, or breastfeeding Have a history of severe allergic reactions to semaglutide, tirzepatide, or any inactive ingredients This is not a replacement for prescribed medical treatment for any health condition

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The appetite suppression that began in the first month becomes more consistent and profound