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The SURPASS-2 trial showing tirzepatide achieving significantly greater HbA1c reduction and weight loss than semaglutide in T2DM patients, and the SURMOUNT trials showing up to 22% average body weight reduction in obese patients, have established tirzepatide as the clinical performance leader in the class

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Higher doses of Mounjaro are associated with greater weight loss, with clinical trials showing a substantial increase in weight loss when increasing from 5 mg to 15 mg

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