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Prolonged reliance on symptom-directed pharmacotherapy should be avoided whenever possible, as dose adjustment remains the most effective strategy for improving tolerability

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Biochem Biophys Res Commun 505(2):523529 Daniels SJ, Leeming DJ, Detlefsen S, Bruun MF, Hjuler ST, Henriksen K, Hein P, Karsdal MA, Brockbank S, Cruwys S (2019) Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-) agonist and a glucagon-like peptide-1 analogue