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The primary outcome is the percentage of participants with absence of NASH with no worsening of fibrosis on liver histology [64]
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To establish whether the MYTHO-WIPI2 interaction occurs on the PtdIns3P-enriched membrane, we expressed in cells a WIPI2 mutant (WIPI2-FTTG), which is unable to bind PtdIns3P, for pull-down experiments
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