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A study of adults with overweight or obesity published in the New England Journal of Medicine found that a once-a-week dosage of semaglutide plus lifestyle changes helped promote sustained weight loss

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In another clinical trial , people with obesity or overweight without diabetes who took a once-weekly injection of 2.4 mg of semaglutide (the maximum dose of Wegovy ) and followed a reduced-calorie diet and regular exercise lost an average of 15% of their weight in 68 weeks (a year and four months)

Many patients taking immunosuppressive or anti-inflammatory medications wonder whether they can safely pursue GLP-1 therapy