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Description
resumed clinical development of its once-daily oral GLP-1 receptor agonist after earlier trials were paused due to gastrointestinal side effects

Obesity-related chronic inflammation contributes not only to the alteration of cardiac metabolism, but also to the accumulation of epicardial adipose tissue, which can aggravate the hemodynamic profile and worsen cardiac function

Drucker Peripherally administered GLP-1R agonists reduce food intake and body weight through signaling mechanisms requiring functional GLP-1Rs in the ARC of the hypothalamus

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