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Methods Adults with T2D treated with 2 glucose-lowering agents who initiated GLP-1 RAs or basal insulin from 2010 to 2019 were propensity-score matched (1:1) and followed until October 2021 (intention-to-treat [ITT])

Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

Semaglutide restless leg syndrome: Explore the current evidence on whether Ozempic or Wegovy causes RLS, potential indirect mechanisms, nutritional factors, and expert guidance on managing leg symptoms during GLP-1 therapy.

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