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02Side-effect tolerability Lower dosing typically means a quieter side-effect profile, which makes long-term adherence realistic for the patients who need it most

For comparison, once-weekly injections of Lillys Zepbound have helped participants shed 15% to 21% of their starting weight after 72 weeks in clinical trials

Most people report appetite suppression returning by week 2-3 on tirzepatide, even at the 2.5 mg dose, because the GIP receptor activation adds effects that semaglutide alone could not provide

May support insulin sensitivity and steadier glucose handling as part of a broader metabolic wellness plan