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In an attempt to curb GLP-1 prescriptions for weight loss and control rising costs, commercial plans have increased GLP-1 prior authorization requirements (e.g., step therapy)

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These pharmacokinetic advantages stem directly from orforglipron's non-peptide nature: as a small molecule, it is inherently resistant to proteolytic degradation in the gastrointestinal tract and does not require the pH-dependent, site-specific absorption mechanisms that constrain peptide-based oral formulations (see our peptide research hub)