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Baek, HM15211, a novel GLP-1/GIP/glucagon triple-receptor co-agonist significantly reduces liver fat and body weight in obese subjects with non-alcoholic fatty liver disease: a phase 1b/2a, multi-center, randomized, placebo-controlled trial, J

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These molecules are administered mainly by sub-cutaneous injection, and as such, remain in the peripheral bloodstream for a long period of time (with half-lives of days), but have little access to the intestinal vagal afferents
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