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Birth issues: The FDA recommends GLP-1s not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because animal studies demonstrate it may cause higher rates of miscarriage and birth defects

Several mechanisms explain why GLP-1 RAs reduce body weight: Central appetite suppression: GLP-1 receptors in the hypothalamus and brainstem alter hunger signalling and food reward

Demographics were defined by patient self-selection for options available in our institution's electronic medical record