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In animal studies, GLP-1RA exposure was associated with reduced fetal growth, delayed skeletal ossification, and reductions in maternal weight gain and food consumption (109)

54 Since Epac2 mediates stimulatory effects of GLP-1 on Ca 2+ influx and mobilization, 49,91,101103 it appears that plasticity exists in the -cell cAMP signaling network such that the HFD leads to an unexpected coupling of glucose metabolism to Epac2 activation and insulin secretion

In actuality, this undermines global health equity by reducing access for countries with universal healthcare or limited budgets

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