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Innovent's mazdutide has gone further: China's NMPA approved mazdutidethe world's first dual GCG [glucagon receptor]/GLP-1 receptor agonistfor chronic weight management in June 2025
A decrease in the level of GLP-1R contributes to neurotoxicity mediated by microglia and astrocytes, exacerbating neuron death and convulsive activity [74]
ARC GABAergic neurons that express thyrotropin-releasing hormone (TRH), approximately 60% of which expressed GLP-1R, were found to have GABAergic afferents directly targeting AgRP neurons
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