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Confirming the metabolic relevance of central GIPR signaling, neuronal loss of GIPR renders mice resistant to GIP-induced body weight loss and GIPR/GLP-1R co-agonism is more potent than selective GLP-1R agonism for weight loss 54

It is worth mentioning that this observation reflects class effect even though not all drugs included in the study like exenatide and lisixenatide, have proven cardiovascular benefits

Pregnancy outcome following maternal exposure to Statins: a multicentre prospective study

Interestingly, DPP-4 inhibition increases circulating endothelial progenitor cells, likely targeting the chemokine stromal-cell-derived factor 1, an important protective system [61]