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The drug primarily increases insulin secretion and decreases glucagon secretion in a glucose-dependent manner
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Both are easy to use, with once-a-week injections making it simple to stick to the treatment plan compared to taking medication every day
The observed divergence in mortality results when comparing injectable semaglutide to sitagliptin (a placebo proxy) in benchmarking analyses led us to view the results for outcomes containing mortality with skepticism and focused our interpretation on the nonmortality clinical endpoints
