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383 However, the development of CETP inhibitors has faced numerous setbacks, 448,449 with several high-profile drug candidates, such as torcetrapib, dalcetrapib, and evacetrapib, failing in phase III clinical trials owing to either a lack of efficacy or off-target adverse effects
Small molecule drugs may offer the possibility of oral administration, which is more convenient and acceptable for patients
It is also about understanding what is happening inside the body
This does not invalidate the research, but it does mean independent replication and broader academic study remain important
