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Lifestyle modifications that support joint health include maintaining a healthy weight to reduce joint load, low-impact activity such as swimming and walking, and following an anti-inflammatory diet

One of the most promising of these frontiers centers on glucagon-like peptide-1, or GLP-1

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It reduces hepatic glucose production, in part through effects on mitochondrial metabolism and activation of AMP-activated protein kinase (AMPK), an enzyme that plays a crucial role in cellular energy homeostasis