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RNA immunoprecipitation (IP) and quantitative PCR JK5366 and JK5574 were raised at 15C until they developed germline tumors as young adults (see tumor assay above)
Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis A two-year carcinogenicity study was conducted in CD-1 mice with doses of 0.2, 0.5, and 1.2 mg/kg/day of pramlintide (32, 67, and 159 times the exposure resulting from the human dose of 360 mcg/day based on area under the plasma concentration curve or AUC, respectively)
