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However, most patients find it hard to lose this much weight and keep it off through lifestyle modifications alone
The expression of pro-inflammatory mediators, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF-), increase in cartilage, bone, and synovium, contributing to the initiation of OA 4,5
Vesicular glutamate transporter (VGLUT), a membrane-bound protein facilitating glutamate trafficking into presynaptic vesicles, is known as a marker for glutaminergic neurons
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