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[DOI] [PubMed] [Google Scholar] 61.Vincent KM, Sharp JW, Raybould HE

Furthermore, ATSP-7041 inhibited the P-gp and BCRP-mediated efflux of the substrate.134 In addition, a clinically significant DDI was reported in a Phase I study of ALRN-6924, an analog of ATSP-7041 and an inhibitor of OATP1B3.135 A patient co-administered with telmisartan (an OATP1B3 substrate) presented with hypotension, which may have been caused by increased exposure of telmisartan mediated by ATSP-7041.135,136 Based on these findings, CYP- and transporter-mediated DDIs involving peptide drugs are not negligible and should be carefully evaluated

Cardiovasc Endocrinol Metabol

Medical specialists serving Alaska populations execute systematic progression frameworks that gradually increase medication levels over designated timeframes