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Consequently, the 2024 American Gastroenterology Association (AGA) Rapid Clinical Practice Update recommends that management should depend on upper gastrointestinal symptoms

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There is limited evidence that patients who fail to respond to tirzepatide will necessarily respond better to other incretin-based therapies, but individual variation may result in differential responses

Month 2: Side effects usually ease, appetite reduction stabilizes, and headaches or lingering GI symptoms may appear occasionally
