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GLP-1 medications slow gastric emptying and may alter gut motility, potentially complicating existing inflammatory patterns or symptom management in IBD patients

This multi-receptor mechanism distinguishes it from existing agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist), and has been associated with pronounced reductions in body weight and improvements in metabolic parameters in early clinical studies

This article aims to provide a comprehensive, research-backed exploration into this query, examining the current scientific understanding of both compounds and the theoretical implications of combining them, particularly in 2026

Results A total of 76 RCTs involving 103 371 patients (mean [SD] age, 57.8 (6.2) years