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This is possible due to the innovative hybrid-silica base of the YMC-Triart Prep stationary phases and combined with the less hydrophobic C4 modification this offers an ideal modification for a polishing purification of Tirzepatide and other challenging GLP-1 peptides

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Heterologous expression in vitro unveiled its constitutive activity capable to raise intracellular cAMP levels through Gs (321) and lead to the secretion of GLP-1 and PYY (89)