does glp 1 cause kidney issues Nephroprotective effects of GLP-1 receptor agonists: where do we stand? | Journal of Nephrology Glucagon-like peptide 1(GLP-1) receptor agonists

Data accumulated from animal experiments conducted in acute ischemic stroke models with and without diabetes have also demonstrated a dose-dependent reduction of infarct volume in the brain by GLP-1RAs, when administered before or during the acute phase of ischemia at reperfusion or with some delay after the onset of reperfusion [60,61,62, 70]

However, the GLP-1R is also involved in adipogenesis in the periphery, which may account for this discrepancy (Challa et al., Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., 2014)

Certain combination therapies are either inappropriate of illogical in DM CKD and all with DM CKD should be afforded Sick day Guidance to afford temporary withdrawal of certain therapies

Some studies warn of pitfalls that can occur when trying to transition away from using the expensive medications, including the regaining of weight, NPR reported