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Studies support that carboxypeptidase A (CPA), a pancreas-derived exo-protease with specificity for C-terminal aromatic and aliphatic amino acid residues, is responsible for the removal of L585 60,63,64,65

Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes

5 The 2018 update focused heavily on the use of glucose-lowering agents to mitigate cardiovascular and renal risks in the context of meeting individualized glycemic goals

Furthermore, the duration of diabetes in the patients included in these studies was relatively short