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Strength training preserves and builds lean mass, which directly supports metabolic rate

Note that GLP-1 is not the only hormone that binds to and signals via the GLP-1R

If GI symptoms persist despite these strategies, some users explore split dosing (microdosing) to reduce peak concentration and smooth out the dose response

By contrast, central injections GLP-1R agonists cause a reduction in food intake (188)