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What's Different And Worth Taking Seriously: The glucagon receptor agonism in retatrutide introduces effects that tirzepatide users haven't had to manage: Heart rate elevation: Retatrutide's Phase 2 data showed a mean increase in resting heart rate of approximately 56 beats per minute at higher doses

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25 Concerns regarding the validity of outcomes have emerged, particularly owing to the reliance on indirect indicators such as the calcitonin test, carcinoembryonic antigen measurement, or vandetanib treatment to distinguish between MTC and non-MTC

Health Canada said it is currently reviewing seven other submissions for generic semaglutide from different companies, with additional regulatory decisions expected in the coming weeks and months [Source: canada.ca/en/health-canada/news/2026/05/canada-approves-second-generic-semaglutide-the-first-g7-country-to-do-so.html]