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The study further noted that metformin improves weight loss by enhancing insulin resistance, promoting appetite suppression through increased GLP-1 and peptide YY (tyrosine-tyrosine) secretion, increasing hypothalamic leptin sensitivity, altering gut microbiome, and inducing growth-differentiating factor 15which collectively reduce food intake and improve metabolic function

Clinical monitoring should include weekly blood glucose logs if you have diabetes, biweekly weight checks, and regular appetite/satiety assessments