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Methods In a randomised, double-blind, three-period crossover study, 31 individuals with T2DM (1864 years, body weight 80120 kg, glycosylated haemoglobin 6.08.5%) received single subcutaneous injections of IcoSema (175 U icodec, 0.5 mg semaglutide), icodec (175 U) or semaglutide (0.5 mg) with 69 weeks washout