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Semaglutide is a synthetic version of a naturally occurring hormone called GLP-1, which is involved in regulating appetite, insulin production and blood sugar levels

For patients experiencing diarrhea or abdominal discomfort, morning administration may be preferable, as it allows symptoms to manifest during daytime hours when patients have easier access to bathroom facilities and can manage hydration more effectively

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The benefits of tirzepatide in HFpEF patients may be attributed to its ability to target key pathophysiological mechanisms of HFpEF, including inflammation and plasma volume expansion 17,18