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When we think about oral formulations of novel weight management products, we need to keep in mind that they are absorbed from the small intestine, enter the portal vein, and are transported to the liver, which mimics physiological pathways of endogenous incretins sectered by various enteroencrine cells

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Likewise, the cardiovascular benefit of efpeglenatide was independent of GFR or the concomitant use of iSGLT-2, suggesting its additive and independent effect from the latter,85 as was also observed in the EXSCEL study.86 A recent meta-analysis of the 8 published cardiovascular safety clinical trials, and which included a total of 60