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(2) GLP-1RAs can also induce Tregs and microglia to secrete IL-10, which further promote microglia to secrete chemokines (Ccl2, Ccl7, and Cxcl10) and IGF-1

3 It enrolled over 300 adults who were overweight or obese (but not diabetic), giving two-thirds of them a daily oral semaglutide dose of 25 mg and the rest a placebo, alongside lifestyle guidance for both groups

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Compared with other PPAR agonists lanifibranor, rosiglitazone,and elafibranor, pioglitazone had a greater effect on steatosis, hepatocyte ballooning, inflammation, and fibrosis