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For example, the glutathione disulfide (GSSG) reduction to glutathione (GSH) is driven by the NADPH generated during the first step of the PPP pathway, when glucose-6-phosphate is converted to 6-P-gluconate
Genetic polymorphisms in organic cation transporter 1 attenuates hepatic metformin exposure in humans
Serious side effects are rare and monitored in ongoing studies
This triple mechanism appears to produce greater metabolic effects, particularly for weight reduction and liver fat content
