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First, GLP-1RA can activate the first messenger adenylate cyclase (AC) after binding to the receptor, which stimulates an increase in the secretion level of the intracellular second messenger cyclic adenosine phosphate (cAMP) and subsequently activates the intracellular secondary messenger protein kinase A (PKA) (48)

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To test whether liraglutide can reverse the inflammatory phenotype of macrophages, LPS-stimulated RAW 264.7 cells were exposed to three increasing doses of liraglutide

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