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[5] [6] The fundamental difference is critical: prescription medications like semaglutide 2.4 mg (Wegovy) and tirzepatide (Zepbound) produce substantial, dose-dependent increases in receptor activation with clinical trial evidence showing approximately 15% and up to 21% body weight reduction, respectively
This effect was attributed to antioxidant properties of DPP-IV, suppression of NF-B, IL-6, TNF-, and elevation of IL-10 (Gonalves et al
