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GLP-1s impact digestion, vagal tone, appetite signaling, bowel motility, and cardiometabolic markers, and they interact with stress physiology and immune activation in ways that can either support or destabilize clients already navigating complex chronic conditions

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in a case of extreme IR (Rabson-Mendenhall syndrome) ( Combination therapy with a GLP-1 RA and a SGLT2i has been reported to involve additional benefits in the management of T2DM compared with monotherapy through different mechanisms ( via an improvement in insulin sensitivity ( Funding This study was supported by Centros de Investigacin Biomdica en Red (CIBER) of Instituto de Salud Carlos III (ISCIII) (CB06/03/0018) and research grants from the ISCIII (PI18/01160), and co-financed by the European Regional Development Fund (ERDF)