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Some patients report reduced hunger and earlier satiety within the first week of treatment, though this varies considerably among individuals

In the post-CVOT era, people living with T2D are now able to benefit from treatments that can provide a therapeutic effect across the cardio-renal metabolic axis of T2D, while their physicians have options to achieve clinically meaningful reductions in CV, HF and renal outcomes, and even to reduce mortality (Fig

These results, using either pharmacology or mouse genetics, show that reduction in CNS GIPR signalling can positively impact peripheral tissue metabolism

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