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SURPASS-CVOT: head-to-head cardiovascular data The SURPASS-CVOT trial compared tirzepatide directly against dulaglutide in patients with type 2 diabetes and established cardiovascular disease
Through irreversible inhibition of cyclooxygenase enzymes, aspirin reduces prostaglandin-mediated inflammation, platelet activation, and downstream tumor-promoting signaling within the colorectal mucosa
This means it activates two hormone receptors simultaneously: the GLP-1 receptor (the same target semaglutide hits) and the GIP receptor (glucose-dependent insulinotropic polypeptide), which semaglutide does not touch at all
